Obstructive sarcoidosis
Identifieur interne : 002082 ( Main/Exploration ); précédent : 002081; suivant : 002083Obstructive sarcoidosis
Auteurs : Petey Laohaburanakit [États-Unis] ; Andrew Chan [États-Unis]Source :
- Clinical Reviews in Allergy & Immunology [ 1080-0549 ] ; 2003-06-01.
English descriptors
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Abstract
Abstract: Sarcoidosis is a systemic granulomatous disease that frequently involves the lung. Although classically thought of as a restrictive lung disease, airway obstruction has become a recognized feature of the disease in the past years. Sarcoidosis can affect the airway at any level and when the involvement includes small airways, it can resemble more common obstructive airway diseases, such as asthma and chronic bronchitis. Pulmonary function testing and high-resolution computerized tomography of the chest are two important tools to evaluate the presence and extent of airway obstruction in sarcoidosis. Pharmacologic options for the treatment of obstructive sarcoidosis are, in large part, not supported by large randomized clinical trials. In severe cases of bronchostenosis owing to sarcoidosis granuloma or extrinsic compression from intrathoracic lymphadenopathy, interventional bronchoscopy has successfully been performed, although repeated procedures are usually required. Lung transplantation is an ultimate option in selected patients with late-stage fibrotic disease.
Url:
DOI: 10.1385/CRIAI:25:2:115
Affiliations:
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Le document en format XML
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Although classically thought of as a restrictive lung disease, airway obstruction has become a recognized feature of the disease in the past years. Sarcoidosis can affect the airway at any level and when the involvement includes small airways, it can resemble more common obstructive airway diseases, such as asthma and chronic bronchitis. Pulmonary function testing and high-resolution computerized tomography of the chest are two important tools to evaluate the presence and extent of airway obstruction in sarcoidosis. Pharmacologic options for the treatment of obstructive sarcoidosis are, in large part, not supported by large randomized clinical trials. In severe cases of bronchostenosis owing to sarcoidosis granuloma or extrinsic compression from intrathoracic lymphadenopathy, interventional bronchoscopy has successfully been performed, although repeated procedures are usually required. Lung transplantation is an ultimate option in selected patients with late-stage fibrotic disease.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Laohaburanakit, Petey" sort="Laohaburanakit, Petey" uniqKey="Laohaburanakit P" first="Petey" last="Laohaburanakit">Petey Laohaburanakit</name></region><name sortKey="Chan, Andrew" sort="Chan, Andrew" uniqKey="Chan A" first="Andrew" last="Chan">Andrew Chan</name><name sortKey="Chan, Andrew" sort="Chan, Andrew" uniqKey="Chan A" first="Andrew" last="Chan">Andrew Chan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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